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Pharmaceutical Development

Our cGMP facility supports all phases of drug product development.

Metrics Contract Services’ Greenville, NC site features more than 93,000 square feet of pharmaceutical drug product development and manufacturing space, all under one roof. That’s double our capacity from only five years ago—driven by demand for high quality, seamless contract services that can deliver products through the pipeline to Phase I, II and III clinical trials.

We custom designed our facility for the formulation pathway.

Metrics Contract Services’ fully integrated, cGMP facility is custom designed to accommodate our experienced team of analytical, pharmaceutical, formulation, quality and manufacturing scientists. Built to exacting specifications, this state-of-the-art facility houses:

  • A dedicated and isolated potent and cytotoxic facility
  • Four analytical laboratories
  • Twelve development rooms (five suites for potent actives, OEL at or above 1mcg/m3 room air)
  • Two suites for potent actives with 100% contained equipment (OEL at or above 30ng/m3 room air)

Metrics Contract Services has an additional 54,000 square foot cGMP warehouse facility utilized for storing cGMP support materials and clean equipment. Click below image for a detailed layout of our building.

Development Equipment List

The following equipment is maintained at our Greenville, NC site:

Blenders

  • Blender; Turbula T2F
  • Blender, V-shell; 1 pt to 2 qt; Patterson-Kelly
  • Blenders (2), V-shell; 1 pt to 16 qt; with Intensifier Bar; GlobePharma
  • Blenders (2), V-shell; 8 qt; Keith Machinery
  • Blender, Cross-flow; 16 qt; Patterson Kelley
  • Blender, Bin-type; 1, 2, 3 cu.ft. (5-30 kg capacity); Flo-Bin
  • Blender, Slant-cone; 3 cu.ft.; Gemco, 1 cu.ft.; Gemco
  • Blender, Double-cone; 10 cu.ft. (120 kg capacity); Bush Industries
  • Blenders (2), Tumble Tote; Totes: (5) 46 cu.ft., (3) 30 cu.ft., (2) 15 cu.ft., (3) 8.5 cu.ft. (50 kg to 400 kg capacity)
  • Blender, Bin-type; 1, 2, 3 cu.ft.; Globe Pharma

Granulators/Mixers

  • Granulator, Vertical-shaft, High-shear (2); up to 1.5 kg; Key KG-5
  • Granulator, Vertical-shaft, High-shear; 8-25 kg; Fielder PMA 25/65
  • Granulator, Vertical-shaft, High-shear; 3-25 kg; Fielder PMA 10/65
  • Granulator, Vertical-shaft, High-shear; 3 kg capacity; Fuji 10-liter
  • Granulator, Vertical-shaft, High-shear (2); 40 kg capacity; Fielder PMA 100
  • Granulator, Vertical-shaft, High-shear; Fielder PMA 400
  • Granulator, Vertical-shaft, High-shear; 40 kg capacity; Sejong SM50
  • Granulator, Oscillating Mill; Frewitt MG-333
  • Roller-Compactor; PowTec RC100x30
  • Roller-Compactor; Fitzpatrick L83
  • Roller-Compactor; Vector TFC-LABO
  • Roller-Compactor; Fitzpatrick IR 220
  • Gerteis Mini-Pactor

Mills/Micronizers

  • Conical mills (5), Quadro Comil Model 197S
  • Conical mill, Quadro Comil Model 196
  • Impact mill, Table-top; Fitzpatrick FitzMill Model L1A
  • Impact mill, Development-scale; Fitzpatrick FitzMill Model M
  • Impact mill, Production-scale; Fitzpatrick FitzMill Model D
  • Micronizer, Jet-type; Development-scale; Fluid Energy Aljet Model 0101

Fluid-Bed Processors/Dryers

  • Fluid-Bed Processor (Dryer/top spray granulating/bead coating); 40/60 liter bowls; Glatt GPCG-10 with 7” Wurster HS and 12” Wurster HS columns
  • Fluid-Bed Processor (Dryer/top spray granulating/bead coating); up to 2 kg capacity; Glatt UniGlatt
  • Fluid-Bed Processor (Dryer/top spray granulating/bead coating); up to 2 kg capacity; Glatt GPCG-1 (2 units)
  • Fluid-Bed Processor (Dryer/top spray granulating/bead coating); 45/100 liter bowls (to 40 kg capacity); O’Hara FBDG-30 with 18” Wurster column
  • Fluid-Bed Processor (Dryer/top spray/granulating); 120 kg capacity; O’Hara FBDG-120
  • Tray Dryer; O’Hara LC II-X
  • Tray Dryer; O’Hara Labcoat M
  • Tray Dryer; Despatch tray oven, 60 kg capacity

Tablet Presses

  • Rotary Presses (2); 10 station, B-tooling, GlobePharma MiniPress II, Piccola PLC-C, SMI Instrumentation
  • Rotary Presses (3); 16 station, B-tooling, SMI Instrumentation; Manesty Betapress
  • Rotary Presses (2); 27 station, B-tooling; Manesty Diamond Unipress
  • Rotary Press; 35 station, B-tooling; Stokes BiLayer Tablet Press
  • Rotary Press; 36 station, B-tooling; Fette 2200i
  • Rotary Press; 24 station, B-tooling; Fette 1200i
  • Single Station Press; Key Minipress SC-2; Globe Pharma MTCM-11
  • Rotary Press; 14 station, B/D tooling, SMI Compacta, SMI Instrumentation
  • Rotary Press; 19 station, B-tooling, SMI Compacta, SMI Instrumentation
  • Rotary Press; 61 station, B-tooling, Fette 3090 double-sided press
  • Korsch XL-100 Instrumented Press

Capsule Fillers

  • Very Low Dose Powder in Capsule Filler; Xcelodose Capsule Filler, 600-S
  • Low Dose Powder in Capsule Filler; Mettler Toledo Quantos QB1
  • Manual Capsule Fillers (8); 100 capsules per tray; Sizes 000, 00, 0, 1, 2, 3, 4, 5; Feton, Inc., Cropharm
  • Semi-Automatic Capsule Fillers (2); 100 capsules per tray; Sizes 0, 1, 2, 3, 4; Dott Bonapace Minicap100
  • Semi-Automatic Capsule Filler; 15,000 capsules/hr.; Sizes 00, 0, 1, 3; Elanco Quali-fill Model 8S
  • Semi-Automatic Capsule Filler; 25,000 Capsules/hr.; Size 0; Shionogi Qualicaps Model 10
  • Automatic Capsule Filler; 400 capsules/minute; Bosch H&K 400; sizes 0, 1, 2, 3, 4, 5, and beadfilling station
  • Automatic Capsule Filler; 330 capsule/minute, Sizes 0, 1, 2, 3, 4, Bosch GKF 330
  • Automatic Capsule Filler; 1500 capsules/minute; Bosch H&K 1500
  • Automatic Capsule Filler; 120 capsules/minute; Bosch H&K 120; sizes 0, 1, 3 change parts
  • HiBar PO510; Hard Gelatin Capsule Liquid Filler

Coating & Printing Equipment

  • Tablet Pan Coater; 15, 24 and 30 inch diameter pans (Tablet Pan Coaters (3); 8.5, 12, 15 and 19 inch diameter pans (200 g to 3 kg); O’Hara LabCoat M & MX
  • Tablet Pan Coater; 48 inch diameter pan (120 kg capacity); O’Hara Fastcoat-48
  • Coating Solution Mixing Tanks; 35, 100, and 125 gallon

Packaging Inspecting Equipment (3 packaging lines)

  • Accumulator Table (3); SureKap Model SKT-36A
  • Bottle Cappers (3); SureKap Model SK6000-S
  • Bottle Labeler (1); NJM-CLI UNI-300V
  • Cap Retorquer (3); SureKap Model SK600
  • Cap Torquer; Swanmatic C-300
  • Conveyor with 2 right angles; SureKap Model SKC4520
  • Induction Sealer (3); Pillar Model 2KW
  • Shrink Tunnel; Axon EZ-24-BR
  • Swift Count/Swift Pack Tablet/Capsule Filler
  • Tablet/Capsule Bottle Filler (2); 60 bottles/minute; Countec Model DMC-60; Countec Model DMC-120
  • Unscrambler Table (2); SureKap Model SKT-36U
  • Portable Induction Sealer; Enercon Compak Jr. and Enercon SuperSeal Jr.
  • Cottoner (2); Lakso 52
  • IMA Bottle Unscrambler (1); Model A300
  • Omega Bottle Unscrambler (1); Model 3D-RP-1-10
  • Omega Shrink Bundler (1); Model FSB-SL-20
  • ZEPF Shrink Bundler (1); Model SA 27
  • NJM/CLI Topserter (1); Model 305VPL
  • NJM/CLI Minicolt 120 Labeler (1)
  • Omega Desiccant Feeder; CDF101
  • Countec Desiccant Feeder; CT-0G-120
  • Inspector (1); MW Technologies
  • In-Line Checkweighers (2); Mettler Hi-Speed XE2
  • Liquid Filler; IMA Fillit and Fillkit
  • Orifice Seating Device; Tirelli Mini-Nebel
  • Video Jet Printer; Model 1210

Balances/Checkweighers

  • Analytical Balances (numerous); Mettler, O’Haus, others
  • Checkweigher/Sorters; Key Int’l Model CW-2001, Sade P4 and (2) Sade P2, Qualicaps CW180, Sade SP140
  • Floor-scales (numerous); Up to 1200 kg capacity, Sartorius, Rice Lake
  • Top-loaders (numerous); Mettler, O’Haus, Sartorius

Test Equipment

  • Moisture Analyzers (2); Arizona Instruments Compu-Trac Max 2000, MA-35 Sartorious
  • Powder/Granule Tap Density Tester; VanKel Model 50-1000
  • Powder/Granule Sonic Sifter (2); Gilson GA-1
  • Tablet Hardness Testers (5); Key Int’l HT-300; HT-500
  • Tablet Friabilators (4); Natoli FT400
  • Tablet/Capsule Disintegration Tester; Van-Kel 71A660A3

Miscellaneous

  • Capsule Bander, Laboratory-scale; Elanco (Shionogi) Quali-Fill
  • Capsule Polisher/Selector (2); Key Int’l CP350
  • Capsule Checkerweighter; Qualicaps CWI-80
  • Extruder; Luwa EXKS-1
  • Liquid Filler; Development-scale (5 mL to 2 liter volumes); Accutek Model SAPD1
  • Marumerizer; Luwa QJ-400
  • Safeline (2); MC 333
  • Metal Detector; Metalchek MET 30+ (3 units)
  • Peristaltic Liquid Pumps (3); Cole-Parmer, MasterFlex
  • Potent Product Containment Flow Hood; 8 ft; Flow Sciences FS2260BKDVA
  • Powder Filler, Laboratory-scale; San Diego Scientific Instruments DOA-2300A
  • Powder Filler (2); All-Fill SHAA SV600 and All-Fill B-350e
  • Low Dose Powder Dispenser; Mettler Toledo Quantos QB1
  • Sifters, Mechanical; MM Industries Vorti-Siv RBF-15 (2), RBF-2; Kason Model 24 (2)
  • Spheronizer; Luwa QJ230
  • Tablet Dedusters (8); Key Int’l CP TD101WD
  • Tablet Thickness Sorter; MW Technologies, RS-200-12
  • Vacuums, Portable HEPA (12); Nilfisk GS-811, GM-80, 3151
  • Vertical Drum Dumper; Custom Design & Machine
  • M.W. Technologies Tablet Sorter; Model RS200-4 (1), Model RS200-12 (1)
  • Tablet and Capsule Inspection System; M.W. Technologies, Model RB-300
  • Tablet and Capsule Printer (2); Hartnett Delta, double sided
  • Jacketed Tank; 350L with bottom agitation
  • Blister Packaging; EZ Blister II, Thermoformed and Cold-formed