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Formulation Development

The right team. The right capabilities. The right choice for formulation development.

At Metrics Contract Services, our focus is simple: Get your compound into the clinic as quickly, as safely and as cost-effectively as possible. That takes:

  • The commitment and know-how of our formulators
  • A strong team of experienced analytical chemists
  • State-of-the-art facilities and equipment, with the underlying quality systems to support them

At Metrics Contract Services, we deliver these critical components for seamless scale-up to commercial manufacturing.

Our experience stands alone. So you don’t have to.

At Metrics Contract Services, our formulation development scientists bring extensive experience. You can count on advanced scientific expertise from PhDs, Master and Registered pharmacists and chemists. Meet some of them here.

You’ll get the benefit of this experience with advice and recommendations regarding:

  • Advanced controlled release technologies
  • Bioavailability enhancement
  • Insoluble actives
  • Unstable actives
  • Potent and toxic actives
  • Small molecule delivery
  • Taste masking (for solid and liquid presentations)

 

Metrics Contract Services offers formulation development services for a wide range of oral dosage forms:

  • Advanced pellet formulations for sustained, pulsed, modified and delayed release
  • Tablets – including coated and matrix
  • Powder and bead-filled capsules
  • Oral liquids and suspensions

Lead Scientists instill confidence. 

We interviewed Metrics Contract Services veteran formulator Joe Cobb, CPIP, about the benefits clients see in working directly with a Metrics Contract Services lead scientist:
“Clients say they have confidence in Metrics Contract Services. They know they can remain with us through multiple phases of development because of our expertise. And they know they will have the same high level of scientific support throughout all of those phases because of the way we’re structured.”



Using Quality by Design to Improve Tablet Strength and Friability

Joe Cobb and his team used the principles of QbD to improve the robustness of a core tablet for a novel modified release oral solid dosage form. View the AAPS 2012 poster and watch a short video below about how Metrics Contract Services applies the principles of QbD to solve formulation development issues.



Delivering full analytical support.

Of course, behind our successful formulators is a team of more than 90 analytical chemists. At Metrics Contract Services, we target a healthy balance of four analytical chemists to every formulator. So we can avoid bottlenecks and backups on the analytical end, and your project stays on track. Review our comprehensive analytical testing services.

Keeping your drug product development and CTM manufacturing under one roof. 

Our 93,000 square foot, cGMP facility features an excellent FDA track record. DEA registered for Schedule II-V controlled substances and equipped with potent and toxic drug handling capabilities, Metrics Contract Services state-of-the-art facilities enable us to navigate the development pathway through Phase I-III all in the same building. View our comprehensive equipment list

Offering full pharmaceutical drug product development services.

Metrics Contract Services offers full formulation development services, including analytical testing and seamless scale-up (including fast track) to Phase I, II and III CTM and commercial manufacturing:

  • SOPs can be used for all phases of the FDA submission process
  • Fast-track development for clinical trial materials in four to six months
  • Batch sizes of less than 1 kg up to 450 kg
  • Seamless scale-up to commercial manufacture

Developing a wide range of oral dosage forms.

Metrics Contract Services offers formulation development services for a wide range of oral dosage forms:

  • Advanced pellet formulations for sustained, pulsed, modified and delayed release
  • Tablets – including coated and matrix
  • Powder and bead-filled capsules
  • Liquids and suspensions

Processes include:

  • Blending
  • Granulation, compacting and mixing
  • Milling and micronizing
  • Fluid bed coating and drying (extrusion and high shear)
  • Spray drying
  • Pellet (bead) and powder encapsulation
  • Powder blending and tableting