Metrics Greenville Facility | High Potent Compound Facility

Our Facility • Greenville Facility

One Campus

Investing over $100m in the last 5 years, we are dedicated to evolving and expanding our facility to meet the needs of our customers. Pairing scientific excellence and robust operational readiness, we maintain a strong FDA record and 95% schedule adherence.

Built with Containment in Mind

Specifically designed for containment and scale-up, our Greenville campus provides a flexible space to proactively solve challenges and progress our customers’ products through the clinical and commercial journey. We specialize in handling potent compounds and small to medium batch sizes, ideal for orphan or targeted drug development.

We currently provide the following services:

Pharmaceutical Drug Development
Pre-clinical and Phase I – III Clinical Trial Materials Manufacturing
Comprehensive Analytical Testing
Stability Storage
Commercial Manufacturing

Our facility is flexible and built to support our customers’ current and future needs. With significant space to expand and continued investment; here at Metrics, when you grow, we grow.

The Features of Our Facility

Pre-Commercial Pharmaceutical Development
- 16 manufacturing suites (11 designed to handle potent compounds) and 2 packaging lines that allow us to support a large variety of development programs
- We can handle controlled substances (CI-CV) as well as potent APIs with OELs down to 30 ng/m³
- Batch sizes ranging from 100g to 450kg
Commercial Manufacturing
- A 126,000 sq-ft facility with 16 manufacturing suites, including a $10MM expansion that brought 3 new suites on stream in June 2021.
- An estimated annual production capacity of 1-2 billion oral solid dose units (combined tablet and capsule production)
- Commercial batch sizes ranging up to 450kg
- Compliance with US FDA and other international regulatory agencies
- Flexible rooms to accommodate potent handling capabilities
- A dedicated Quality Control Laboratory
Analytical Testing
- Over 150 exceptionally talented analytical scientists
- 25,000 sq-ft of analytical laboratory space
- Services include Method Development, Method Validation, Sample Analysis, Release Testing, Stability Study Storage and Testing, Physical Characterization, Trace Metals Analysis, and Microbiology
- A wide range of analytical instrumentation including – HPLC, UPLC, GC, LC-MS, Dissolution Apparatus and more
Stability Storage
Located at the Greenville campus, we offer a 17,000 sq-ft stand-alone Stability Center of Excellence that features:
- 6,000-7,000 sq-ft of space for most International Conference on Harmonisation (ICH) storage conditions
- 100-percent back-up power generation providing 1,200 kilowatts of electricity, fueled by an uninterrupted supply of natural gas
- Integrated system redundancies for HVAC, chillers and humidifiers
- 100-percent seamless and sealed construction inside and outside units
- Specialty climatic mapping and tolerances that include each ICH stability zone for temperature and humidity
- Sufficient square footage to double the number of chambers initially installed, providing room to grow for years
Systems used in the Center meet ICH Guidelines Q1A for Stability Testing and Q1B for Photostability Testing, and comply with guidelines established by the FDA, WHO and the European Medicines Agency’s Committee for Proprietary Medicinal Products.