Chromatography

We provide a vast range of High Pressure Liquid Chromatography, Ultra-Performance Liquid Chromatography, Gas Chromatography and Ion Chromatography systems.

We have extensive capacity to support your development project.

  • High Pressure Liquid Chromatography (HPLC)

    • Over 100 HLPC units in operation
    • Stability-indicating gradient HPLC methods for drug substances and drug products
    • Isocratic HPLC methods to support nonstability-indicating tests (Dissolution, Content Uniformity)
    • Chiral, Gel Permeation, Reversed-phase, Normal-phase, Ion-pairing, and Ion Exchange separations
    • Forced degradation studies
    • UV/VIS (including PDA), Refractive Index, Evaporative Light Scattering, and Mass Spectroscopic detection
    • Agilent 6530 Accurate Mass Q-TOF equipped with ESI and APCI for MS and MS/MS analyses
  • Ultra-Performance Liquid Chromatography (UPLC)

    • Development of rapid UPLC methods including conversion of traditional methods to UPLC
    • Systems include Waters Acquity H-Class and Shimadzu Prominence UFLC
    • Refractive index measurement, UV, fluorescence, CAD, conductivity, and diode-array detection
  • Gas Chromatography (GC)

    • Residual Solvents methods (compendial and non-compendial) for drug substances, raw materials, and drug products
    • Assay methods for non-solvent volatile impurities and intermediates
    • Headspace and direct injection sample introduction for packed and capillary columns
    • Flame Ionization (FID), Thermal Conductivity (TCD), and Mass Spectroscopic (MS) detection
  • Ion Chromatography (IC)

    • Analysis of inorganic cations and anions; organic acids and bases; as well as amino acids and proteins
    • Analysis of mono-, di-, oligosaccharide, polysaccharide and their derivatives
    • Multiple Dionex Ion Chromatographic HPLCs available with Conductivity and Amperometric detection

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