Less than 1 min 22/08/20

Identifying the Structure of an Unknown Impurity in a Topical Gel

It is not uncommon for pharmaceutical analytical chemists to observe unknown impurities during routine drug product testing using general chromatographic methods such as high-pressure liquid chromatography/ultraviolet or gas chromatography/flame ionization detection. Discovery of an unknown impurity triggers an investigation, along with a shift in priorities from routine to more specialized testing to answer key questions about the impurity.

Pharmaceutical Technology spoke with experts from Metrics Contract Services who shared a case study, highlighting analytical instrumentation and techniques that were used to identify an unknown impurity detected during routine release testing of a topical gel drug product. Read the full article here.


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