Meet the Scientist: Jennie Winstead
How long have you been with Metrics Contract Services?
About four years.
What is your role?
Team Leader, Method Development/Method Validations
What accomplishment/project/area of work is your specialty or makes you proud?
I like solving complex problems for our clients and making ideas come to fruition.
Are there any special organizational strategies you use to be efficient at work?
I typically like to prioritize by deadlines and work backwards. This helps me see the big picture and then narrow the scope to ensure all the details and information are included in the final package.
What’s are your team’s latest achievements?
Our team is comprised of nine chemists, two team leads and one group leader. We have just finished a complex forced degradation study for one client and a complex 2-stage dissolution method validation for another client.
For the forced degradation study: the active tautomerizes under hydrolysis into two known degradants. This required a change in how our stressing agents were made for the acid and base pathways. We had to modify the solvent used to prepare the stressing agents to minimize this reaction.
For the dissolution validation: This compound was a BCS class IV. There were solution stability issues in the acid stage of the method. We suspected that the filter membrane being used was not stopping the dissolution completely and allowing undissolved API to go into the filtrate. The undissolved API was going into solution and increasing the amount found over time. We performed a filter study and changed the filter membrane type. This solved the solution stability issue in the acid stage and worked for the buffer stage as well.
Our entire team worked together to ensure these projects were met.
How do you think those accomplishments might impact the contract pharmaceutical industry and the industry at large?
Our technical expertise and experiences will allow us to build off of these accomplishments to further help our clients in the future. We are always learning new things and ways of solving problems as a team using our scientific knowledge and open communication which allows ideas to flourish.
What is the most rewarding part of your job?
See the members of my team proud of the work they have performed and projects they have accomplished. I enjoy mentoring my team and watching them grow in their careers.
What is the best piece of advice you ever received from one of your mentors/colleagues?
The best piece of advice I have ever received was this: “It is not whether you made a mistake, it is how you recover from your mistakes that matter. No one’s perfect. Being accountable and moving forward is more important than being perfect.’’ Science isn’t perfect. Science is always proving and disproving facts. It is how we react to those findings that help us with our careers.