An increasing number of highly potent and complex small molecule formulations are entering development pipelines. A preferred dosage form, oral solid dose (OSD) formulations, continue to lead drug research, development, and approvals, with 2019 seeing the highest percentage of OSD approvals since 2013.
Over the past decade, many of the innovative and novel formulations introduced by the pharma industry have had to address poorly water-soluble active pharmaceutical ingredients (APIs). Considering the pace of drug development, overcoming solubility issues will remain an ongoing issue.
In this article, Dr. Vinod Patil, Manager of Pharmaceutical Development at Metrics Contract Services, unpacks the solubility challenge with application to a recent case study exploring how Metrics successfully supported a clinical trial with multiple formulation development deliverables. Read the full article here.