Enteric polymer coatings create a protective gastro-resistant barrier that prevents oral medication from dissolving or disintegrating in the stomach before it reaches the small intestine.
Although enteric polymer coatings have long been used in tablet formulations for controlled drug delivery systems, little research has been conducted to evaluate coatings for capsule drug formulations.
Enteric coating may be necessary to either protect acid-sensitive active pharmaceutical ingredient (API) from gastric conditions, or to create a controlled release drug delivery system. Some APIs degrade in low pH conditions, and typically would be destroyed in the harsh environment in the stomach. This creates a need to protect sensitive APIs used in oral dosage forms.
Optimizing release based on location allows scientists to design drugs targeted to release, for example, only at the large intestine.
Ideally, an excipient needs to be inert to both the patient’s body as well as other ingredients in the formulation. If the excipient is not inert, it may cause undesired reactions, preventing bioavailability for the patient or causing additional impurities to form.
For this study, enteric-coated capsules were prepared and allowed to sit in dissolution vessels containing acidic media. The ability of the enteric coating to properly seal and protect capsule contents through various analytical tests was examined and analyzed.
Find out the results of the study and the enteric polymers used within it in this white paper.